Results and Reports
Axis 1. Predictive Medicine (COHORTE Program)
The IMPaCT Cohort Axis has developed and launched the structure for recruiting the 200,000 participants who will take part in the prospective study. This structure consists of 50 nodes distributed throughout the entire country, including the 17 Autonomous Communities and the two Autonomous Cities.
A model of Informed Consent has been established for the collection and analysis of data and information gathered from participants.
In addition, the variables of interest for measurement have been selected and studied, along with the corresponding questionnaires, the biological samples to be collected, and the physical tests to be performed on participants. These components have been tested and validated in pre-pilot studies.
In 2023, recruitment of the first participants began in the Autonomous Communities of Aragón, Balearic Islands, Castilla-La Mancha, and Madrid.
Reports
Axis 2. Data Science (DATA Program)
The IMPaCT-Data Axis has developed a series of recommendations and best practices for collecting electronic health record information, medical images, and genomic data, as well as for ensuring interoperability among all this information.
Complementing this work, a cloud infrastructure architecture has been designed to provide a virtual research environment for the analysis of genomic, clinical, and medical imaging data. More information on the conceptualization of this cloud and demonstrators of the recommended technologies can be found at this link.
The axis has also compiled a set of software tools for data analysis, which are available at the bio.tools domain.
Reports
- Guide to Best Practices for Software Development and Maintenance
- Requirements of an EGA Local Node
- Description of EGA Community Instance Interfaces
- Genomic Analysis in Healthcare Settings
- EHR International Reporting Standards
- Comparison of EHR Information Management Techniques
- International Medical Imaging Information Annotation Standards
- Comparison of Medical Image Information Management Techniques
- Biomedical Data Integration Techniques
- Technical Requirements for Beacon Systems Commissioning
- Revised Specifications for the Inclusion of Biomedical Medical Imaging Markers
- Security aspects in the handling of sensitive data
- E1.6.3. Training Activities Report (Year 3) (M40, v.1.0)
- E2.5. Software Indicators Report
- E3.3. Final Report of an EGA Node (M43, v.1.0)
- E3.5. Comparative Analysis of Processes in Hospital Environments (v1.0)
- E5.2-3 Biomedical Data Integration Demonstrator. Architecture, Deployment, and Evaluation (M42, v.0.1)
- E5.6 Final Report on the Functioning of the IMPaCT Beacon Network (M42, v.1.0)
Axis 3. Genomic Medicine (GENÓMICA Program)
The IMPaCT Genomics Axis has developed a series of Standard Operating Procedures for the proper execution of genomic analyses and the management of the data obtained, as well as for the standardization and harmonization of the information and criteria used.
Expert groups have been formed within the axis in various disciplines. As a result of their work, a series of gene-specific and drug-specific guidelines have been produced, along with several models (diagnostic report, genetic report, clinical recommendation, etc.).
Policies have also been developed to ensure the protection of participants’ rights, which have been reviewed by the relevant ethics committees. The objectives are to guarantee transparency, respect for individuals’ decisions, traceability and security throughout the entire data handling process, and the protection of vulnerable individuals.
Reports
- Basic requirements based on ISO 15189 applied to Pharmacogenetics
- Clinical Implementation Recommendations Guide
- Implementation Recommendations Guide for Aripiprazole
- Sequencing Results Report
- Hereditary cancer diagnosis report
- Report Massive Sequencing (COD) Results
- Guidelines for the interpretation of variants in cancer genes
- Genetic Report Template
- Diagnostic report template
- Clinical recommendation model
- Medical Infographics
- Patient Infographics
- Clinical guidelines for the drugs studied
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