Infraestructura de Medicina de Precisión asociada a la Ciencia y la Tecnología
IMPaCT MEETING
18 Nov 2024 – form 09:30 to 18:00

AMBISiON-IMPaCT: Enrichment of the IMPaCT cohort with ENVIRONMENTAL and Eye Health measures for preventive precision medicine

PMP24/00008
Year: 2025
Autonomous Communities: MADRID

Axes of Affiliation

Line of research

Project Video

Summary

The AMBISiON-IMPaCT project, promoted by the IMPaCT cohort itself, has as its main objective to improve the collection of data on environmental exposures and their ability to detect their health effects early.

The IMPaCT cohort, currently in the deployment phase, aims to recruit 200,000 participants, although so far it has incorporated 5,500. As the AMBISiON-IMPaCT project will last only two years, the analysis of biological samples from participants already recruited would be unsustainable and of limited utility. For this reason, the project will focus its efforts on developing tools that allow for the automated and prospective integration of environmental exposure information into the cohort data system.

 

This information will be obtained through questionnaires, geospatial sources and air quality models, which will be linked to each participant’s residential data and personal monitors. In this way, personalized measures of exposure to environmental factors will be generated for the entire cohort, taking advantage of the potential of its large size.

 

In addition, predictive models of disease risk will benefit from tools for the early detection of cardiometabolic and neurological effects. Among them, high-resolution ocular imaging technologies will make it possible to create a bank of fundus images, similar to that of the UK Biobank, with the aim of using it as a biomarker of early effect. As an added value, AMBISiON-IMPaCT will promote research in personalized preventive medicine in eye health, with the purpose of reducing visual impairment.

 

Ultimately, AMBISiON-IMPaCT will qualitatively strengthen the IMPaCT cohort in three key areas:

  1. It will allow combining environmental exposures and genetic information to define personalized prevention strategies.
  2. It will enrich the cohort with ocular biomarkers to detect early effects and accelerate the achievement of useful results.
  3. It will incorporate the study of the causes and prevention of visual impairment, an aspect that cannot currently be addressed with the available information.

Coordinator and Institution

Principal Investigator
Esther García García-Esquinas / Maria José Sánchez
Institution
Objectives
Impact

The project will promote precision preventive medicine in Spain through the consolidation of the IMPaCT cohort.

  1. By incorporating environmental data, it will allow for the construction of more accurate predictive models of diseases that help clinical and public health decision-making.
  2. The generation of a retinal image bank, similar to the one existing in the UK Biobank, will lay the foundations for future studies on precision medicine in Spain, allowing: 1) To advance in the understanding of the pathophysiological processes of a large number of systemic diseases; 2) To promote the discovery of retinal signatures for early diagnosis and for the establishment of new therapeutic targets; 3)

To evaluate the usefulness of these signatures as biomarkers of early damage related to environmental exposures; and 4) To develop predictive models that combine retinal biomarkers with genetic and environmental information for the development of precision medicine.

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